2008

C. Farny and G.T. Clement, "A feasibility study of ultrasound phase angle contrast for heating localization," Journal of the Acoustical Society of America 123 (3) 2008, IN PRESS.

2007

White PJ and Clement GT, "Two-Dimensional Localization with a Single Diffuse Ultrasound Field Excitation," IEEE TUFFC. 2007 Nov;54(11):2309-17.

Elizabeth A. Stewart, MD, Bobbie Gostout, MD, Jaron Rabinovici, MD, Hyun S. Kim, MD,Lesley Regan, MD, and Clare M. C. Tempany, MD, "Sustained Relief of Leiomyoma Symptoms by Using Focused Ultrasound Surgery," Obstet Gynecol 2007;110:279–87.

S-C. Tang, and G.T. Clement "A harmonic cancellation technique for an ultrasound transducer excited by a switched-mode power converter," IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 2008 IN PRESS

White PJ, Palchaudhuri S, Hynynen K, Clement GT. "The effects of desiccation on skull bone sound speed," IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 2007 54 (8), 1708-1710

S-C. Tang, G.T. Clement, K. Hynynen, "A computer-controlled ultrasound pulser-receiver system from transskull fluid detection using a shear wave detection technique," IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 2007; 54(9) 1772-1783.

K. Hynynen and G.T.Clement, "Clinical applications of High Intensity Focused Ultrasound: The Brain," International Journal of Hyperthermia, 2007 23 (2) 193-202.

G.T.Clement, "Two-dimensional ultrasound detection with unfocused frequency-randomized signals," J Acoust Soc Am. 121(1):636-647 (2007).

N.McDannold, N.Vykhodtseva, K.Hynynen, "Use of ultrasound pulses combined with Definity for targeted blood-brain barrier disruption: A feasibility study," Ultrasound Med Biol. (2007).

S.Raymond, J.Skoch, B.Bacskai, K.Hynynen, "Modular design for in vivo optical imaging and ultrasound treatment in the murine brain," IEEE Trans Ultrason Ferroelectr Freq Control. 54(2):431-4 (2007).

M.Kinoshita, Y.Eguchi, K.Hynynen, "Activation of Bak in ultrasound-induced, JNK- and p38-independent apoptosis and its inhibition by Bcl-2," Biochem Biophys Res Commun. 353(2):515-21 (2007).

2006

N.Vykhodtseva, N.McDannold, K.Hynynen, "Induction of apoptosis in vivo in the rabbit brain with focused ultrasound and Optison," Ultrasound Med. Biol. 32(12):1923-9 (2006).

N.McDannold, K.Hynynen, "Quality assurance and system stability of a clinical MRI-guided focused ultrasound system: four-year experience," Med. Phys. 33(11):4307-13 (2006).

N.McDannold, N.Vykhodtseva, K.Hynynen, "Microbubble contrast agent with focused ultrasound to create brain lesions at low power levels: MR imaging and histologic study in rabbits," Radiology. 241(1):95-106 (2006).

N.Sheikov, N.McDannold, F.Jolesz, Y.Z.Zhang, K.Tam, K.Hynynen, "Brain arterioles show more active vesicular transport of blood-borne tracer molecules than capillaries and venules after focused ultrasound-evoked opening of the blood-brain barrier," Ultrasound Med. Biol. 32(9):1399-409 (2006).

K.Hynynen, N.McDannold, G.Clement, F.A.Jolesz, E.Zadicario, R.Killiany, T.Moore, and D.Rosen, "Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain- A primate study," Eur. J. Radiol. 59(2):149-56 (2006).

K.Hynynen, N.McDannold, N.Vykhodtseva, S.Raymond, R.Weissleder, F.A.Jolesz, and N.Sheikov, "Focal disruption of the blood-brain barrier by 260 khz ultrasound bursts - a method for molecular imaging and targeted drug delivery," J. Neurosurgery. 105(3):445-454(2006).

M.Kinoshita, N.McDannold, F.Jolesz, K.Hynynen, "Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption," Proc Natl Acad Sci U S A. 103(31):11719-23 (2006).

X.Yin, L.Epstein, K.Hynynen, "Noninvasive transesophageal cardiac thermal ablation using a 2-D focused, ultrasound phased array: a simulation study," IEEE Trans Ultrason Ferroelectr Freq Control. 53(6):1138-49 (2006).

M.Kinoshita and K.Hynynen, "Mechanism of porphyrin-induced sonodynamic effect: possible role of hyperthermia," Radiat. Res. 165(3), 299-306 (2006).

M.Kinoshita, N.McDannold, F.A.Jolesz, and K.Hynynen, "Targeted delivery of antibodies through the blood-brain barrier by MRI-guided focused ultrasound," Biochem. Biophys. Res. Commun. 340(4), 1085-90 (2006).

P.J.White, G.T.Clement, and K.Hynynen,"Longitudinal and shear mode ultrasound propagation in human skull bone," Ultrasound Med Biol. 32(7):1085-96 (2006).

N.McDannold, C.M.Tempany, F.M.Fennessy, M.J.So, F.J.Rybicki, E.A.Stewart, F.A.Jolesz, and K.Hynynen,"Uterine leiomyomas: MR imaging-based thermometry and thermal dosimetry during focused ultrasound thermal ablation," Radiology 240(1), 263-72 (2006).

N.McDannold, N.Vykhodtseva, and K.Hynynen,"Targeted disruption of the blood–brain barrier with focused ultrasound: association with cavitation activity," Phys. Med. Biol. 51793-807 (2006).

S.B.Raymond, J.Skoch, K.Hynynen, and B.J.Bacskai,"Multiphoton imaging of ultrasound/Optison mediated cerebrovascular effects in vivo," J. Cereb. Blood Flow Metab (2006).

P.J.White, G.T.Clement, and K.Hynynen,"Local frequency dependence in transcranial ultrasound transmission," Phys. Med. Biol. 51(9), 2293-305 (2006).

2005

J. Aarnio, G. T. Clement, and K. Hynynen, “A new ultrasound method for determining the acoustic phase shifts caused by the skull bone,” Ultrasound Med. Biol. 31(6), 771-80 (2005).

G.T.Clement, J.Huttunen, and K.Hynynen, “Superresolution ultrasound imaging using back-projected reconstruction,” J. Acoust. Soc. Am. 118(6), 3953-60 (2005).

G. T. Clement and K. Hynynen, “Ultrasound phase-contrast transmission imaging of localized thermal variation and the identification of fat/tissue boundaries,” Phys. Med. Biol. 50(7), 1585-600 (2005).

G. T. Clement, P. J. White, R. L. King, N. McDannold, and K. Hynynen, “A Magnetic Resonance Imaging-Compatible, Large-Scale Array for Trans-Skull Ultrasound Surgery and Therapy,” J. Ultrasound Med. 24(8), 1117-25 (2005).

G.T.Clement, “Spectral image reconstruction for transcranial ultrasound measurement,” Phys. Med. Biol. 50(23), 5557-72 (2005).

M. D. Hurwitz, I. D. Kaplan, J. L. Hansen, S. Prokopios-Davos, G. P. Topulos, K. Wishnow, J. Manola, B. A. Bornstein, and K. Hynynen, “Hyperthermia combined with radiation in treatment of locally advanced prostate cancer is associated with a favourable toxicity profile,” Int. J. Hyperthermia 21(7), 649-56 (2005).

T. Huttunen, M. Malinen, J. P. Kaipio, P. J. White, and K. Hynynen, “A full-wave Helmholtz model for continuous-wave ultrasound transmission,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 52(3), 397-409 (2005).

K. Hynynen, N. McDannold , N. A. Sheikov, F. A. Jolesz, and N. Vykhodtseva, “Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications,” Neuroimage 24(1), 12-20 (2005).

F. A. Jolesz, K. Hynynen, N. McDannold, and C. Tempany, “MR Imaging-Controlled Focused Ultrasound Ablation: A Noninvasive Image-Guided Surgery,” Magn Reson. Imaging Clin. N. Am. 13(3), 545-60 (2005).

M. Kinoshita and K. Hynynen, “Intracellular Delivery of Bak BH3 Peptide by Microbubble-Enhanced Ultrasound,” Pharm. Res. 22(5), 716-20 (2005).

M. Kinoshita and K. Hynynen, “A novel method for the intracellular delivery of siRNA using microbubble-enhanced focused ultrasound,” Biochem. Biophys. Res. Commun. 335(2), 393-9 (2005).

H. Liu, N. McDannold , and K. Hynynen, “Focal beam distortion and treatment planning in abdominal focused ultrasound surgery,” Med. Phys. 32(5), 1270-80 (2005).

M. Malinen, T. Huttunen, J. P. Kaipio, and K. Hynynen, “Scanning path optimization for ultrasound surgery,” Phys. Med. Biol. 50(15), 3473-90 (2005).

N. McDannold , N. Vykhodtseva, S. Raymond, F. A. Jolesz, and K. Hynynen, “MRI-guided targeted blood-brain barrier disruption with focused ultrasound: Histological findings in rabbits,” Ultrasound Med. Biol. 31(11), 1527-37 (2005).

N. McDannold, “Quantitative MRI-based temperature mapping based on the proton resonant frequency shift: Review of validation studies,” Int. J. Hyperthermia 21(6), 533-46 (2005).

S. B. Raymond and K. Hynynen, “Acoustic transmission losses and field alterations due to human scalp hair,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 52(8), 1415-9 (2005).

E. Sassaroli and K. Hynynen, “Resonance frequency of microbubbles in small blood vessels: a numerical study,” Phys. Med. Biol. 50(22), 5293-305 (2005).

C. E. Silcox, R. C. Smith, R. King, N. McDannold, P. Bromley, K. Walsh, and K. Hynynen, “MRI-guided ultrasonic heating allows spatial control of exogenous luciferase in canine prostate,” Ultrasound Med. Biol. 31(7), 965-70 (2005).

S. D. Sokka, T. P. Gauthier, and K. Hynynen, “Theoretical and experimental validation of a dual-frequency excitation method for spatial control of cavitation,” Phys. Med. Biol. 50(9), 2167-79 (2005).

E. A. Stewart, M. J. So, F. M. Fennessy, N. J. McDannold, K. Hynynen, and C. M. Tempany, “OC1. 03: High-intensity focused ultrasound: the treatment of uterine fibroids and other potential applications,” Ultrasound Obstet. Gynecol. 26(4), 309 (2005).

J. White, G. T. Clement, and K. Hynynen, “Transcranial ultrasound focus reconstruction with phase and amplitude correction,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 52(9), 1518-22 (2005).

X. Yin and K. Hynynen, “A numerical study of transcranial focused ultrasound beam propagation at low frequency,” Phys. Med. Biol. 50(8), 1821-36 (2005).

2004

A. Abdollahi, S. Domhan, J. W. Jenne, M. Hallaj, G. Dell' Aqua, M. Mueckenthaler, A. Richter, H. Martin, J. Debus, W. Ansorge, K. Hynynen, and P. E. Huber, “Apoptosis signals in lymphoblasts induced by focused ultrasound,” FASEB J. (2004).

G. T. Clement, P. J. White, and K. Hynynen, “Enhanced ultrasound transmission through the human skull using shear mode conversion,” J. Acoust. Soc. Am. 115(3), 1356-64 (2004).

G.T.Clement, “Perspectives in clinical uses of high-intensity focused ultrasound,” Ultrasonics 42(10), 1087-93 (2004).

C. W. Connor and K. Hynynen, “Patterns of thermal deposition in the skull during transcranial focused ultrasound surgery,” IEEE Trans. Biomed. Eng 51(10), 1693-706 (2004).

J. Hindley, W. M. Gedroyc, L. Regan, E. Stewart, C. Tempany, K. Hynynen, N. McDannold, Y. Inbar, Y. Itzchak, J. Rabinovici, K. Kim, J. F. Geschwind, G. Hesley, B. Gostout, T. Ehrenstein, S. Hengst, M. Sklair-Levy, A. Shushan, and F. Jolesz, “MRI guidance of focused ultrasound therapy of uterine fibroids: early results,” AJR Am. J. Roentgenol. 183(6), 1713-9 (2004).

K. Hynynen, G. T. Clement, N. McDannold, N. Vykhodtseva, R. King, P. J. White, S. Vitek, and F. A. Jolesz, “500-element ultrasound phased array system for noninvasive focal surgery of the brain: A preliminary rabbit study with ex vivo human skulls,” Magn Reson. Med. 52(1), 100-7 (2004).

K. Hynynen and N. McDannold, “MRI guided and monitored focused ultrasound thermal ablation methods: a review of progress,” Int. J. Hyperthermia 20(7), 725-37 (2004).

F. A. Jolesz, K. Hynynen, N. McDannold, D. Freundlich, and D. Kopelman, “Noninvasive thermal ablation of hepatocellular carcinoma by using magnetic resonance imaging-guided focused ultrasound,” Gastroenterology 127(5 Suppl 1), S242-S247 (2004).

E. E. Konofagou, M. Ottensmeyer, S. Agabian, S. L. Dawson, and K. Hynynen, “Estimating localized oscillatory tissue motion for assessment of the underlying mechanical modulus,” Ultrasonics 42(1-9), 951-6 (2004).

M. Malinen, T. Huttunen, K. Hynynen, and J. P. Kaipio, “Simulation study for thermal dose optimization in ultrasound surgery of the breast,” Med. Phys. 31(5), 1296-307 (2004).

S. Maruvada and K. Hynynen, “Optical monitoring of ultrasound-induced bioeffects in glass catfish,” Ultrasound Med. Biol. 30(1), 67-74 (2004).

N. McDannold, N. Vykhodtseva, F. A. Jolesz, and K. Hynynen, “MRI investigation of the threshold for thermally induced blood-brain barrier disruption and brain tissue damage in the rabbit brain,” Magn Reson. Med. 51(5), 913-23 (2004).

N. McDannold , R. L. King, and K. Hynynen, “MRI monitoring of heating produced by ultrasound absorption in the skull: in vivo study in pigs,” Magn Reson. Med. 51(5), 1061-5 (2004).

N. McDannold, S. L. Fossheim, H. Rasmussen, H. Martin, N. Vykhodtseva, and K. Hynynen, “Heat-activated Liposomal MR Contrast Agent: Initial in Vivo Results in Rabbit Liver and Kidney,” Radiology 230(3), 743-52 (2004).

E. Sassaroli and K. Hynynen, “Forced linear oscillations of microbubbles in blood capillaries,” J. Acoust. Soc. Am. 115(6), 3235-43 (2004).

N. Sheikov, N. McDannold, N. Vykhodtseva, F. Jolesz, and K. Hynynen, “Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles,” Ultrasound Med. Biol. 30(7), 979-89 (2004).

2003

G. T. Clement and K. Hynynen, “Forward planar projection through layered media,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 50(12), 1689-98 (2003).

T. Giesecke and K. Hynynen, “Ultrasound-mediated cavitation thresholds of liquid perfluorocarbon droplets in vitro,” Ultrasound Med. Biol. 29(9), 1359-65 (2003).

P. E. Huber, M. J. Mann, L. G. Melo, A. Ehsan, D. Kong, L. Zhang, M. Rezvani, P. Peschke, F. Jolesz, V. J. Dzau, and K. Hynynen, “Focused ultrasound (HIFU) induces localized enhancement of reporter gene expression in rabbit carotid artery,” Gene Ther. 10(18), 1600-7 (2003).

T. Huttunen, J. P. Kaipio, and K. Hynynen, “Modeling of anomalies due to hydrophones in continuous-wave ultrasound fields,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 50(11), 1486-500 (2003).

K. Hynynen, N. McDannold, H. Martin, F. A. Jolesz, and N. Vykhodtseva, “The threshold for brain damage in rabbits induced by bursts of ultrasound in the presence of an ultrasound contrast agent (Optison®),” Ultrasound Med. Biol. 29(3), 473-81 (2003).

R. L. King, G. T. Clement, S. Maruvada, and K. Hynynen, “Preliminary results using ultrasound transmission for image-guided thermal therapy,” Ultrasound Med. Biol. 29(2), 301-7 (2003).

E. Konofagou, J. Thierman, and K. Hynynen, “The use of ultrasound-stimulated acoustic emission in the monitoring of modulus changes with temperature,” Ultrasonics 41(5), 337-45 (2003).

E. E. Konofagou and K. Hynynen, “Localized harmonic motion imaging: theory, simulations and experiments,” Ultrasound Med. Biol. 29(10), 1405-13 (2003).

P. A. Lewin, N. Barrie-Smith, M. Ide, K. Hynynen, and M. Macdonald, “Interlaboratory acoustic power measurement,” J. Ultrasound Med. 22(2), 207-13 (2003).

N. McDannold, M. Moss, R. Killiany, D. L. Rosene, R. L. King, F. A. Jolesz, and K. Hynynen, “MRI-guided focused ultrasound surgery in the brain: Tests in a primate model,” Magn Reson. Med. 49(6), 1188-91 (2003).

S. D. Sokka, R. King, and K. Hynynen, “MRI-guided gas bubble enhanced ultrasound heating in in vivo rabbit thigh,” Phys. Med. Biol. 48(2), 223-41 (2003).

E. A. Stewart, W. M. H. Gedroyc, C. M. C. Tempany, B. J. Quade, Y. Inbar, T. Ehrenstein, A. Shushan, J. T. Hindley, R. D. Goldin, M. David, M. Sklair, J. Rabinovici, Y. Itzchak, N. McDannold, K. Hynynen, F. A. Jolesz, J. W. Oestmann, S. Yagel, A. Revel, M. Gomori, and L. Regan, “Focused ultrasound treatment of uterine fibroids: safety and feasibility of a noninvasive thermoablative technique,” Am. J. Obstet. Gynecol. 189(1), 48-54 (2003).

C. M. Tempany, E. A. Stewart, N. McDannold, B. J. Quade, F. A. Jolesz, and K. Hynynen, “MR Imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study,” Radiology 226(3), 897-905 (2003).

A. Vanne and K. Hynynen, “MRI feedback temperature control for focused ultrasound surgery,” Phys. Med. Biol. 48(1), 31-43 (2003).

2002

G. T. Clement and K. Hynynen, “Correlation of ultrasound phase with physical skull properties,” Ultrasound Med. Biol. 28(5), 617-24 (2002).

G. T. Clement and K. Hynynen, “A non-invasive method for focusing ultrasound through the human skull,” Phys Med. Biol. 47(8), 1219-36 (2002).

G. T. Clement and K. Hynynen, “Micro-receiver guided transcranial beam steering,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 49(4), 447-53 (2002).

C. W. Connor and K. Hynynen, “Bio-acoustic thermal lensing and nonlinear propagation in focused ultrasound surgery using large focal spots: a parametric study,” Phys Med. Biol. 47(11), 1911-28 (2002).

C. W. Connor, G. T. Clement, and K. Hynynen, “A unified model for the speed of sound in cranial bone based on genetic algorithm optimization,” Phys. Med. Biol. 47(22), 3925-44 (2002).

M. D. Hurwitz, I. D. Kaplan, J. L. Hansen, S. Prokopios-Davos, G. P. Topulos, K. Wishnow, J. Manola, B. A. Bornstein, and K. Hynynen, “Association of rectal toxicity with thermal dose parameters in treatment of locally advanced prostate cancer with radiation and hyperthermia,” Int. J. Radiat. Oncol. Biol. Phys 53(4), 913-8 (2002).

F. A. Jolesz and K. Hynynen, “Magnetic resonance image-guided focused ultrasound surgery,” Cancer J. 8 Suppl 1S100-S112 (2002).

F. A. Jolesz, I. Talos, R. B. Schwartz, H. Mamata, D. F. Kacher, K. Hynynen, N. McDannold, P. Saiviroonporn, and L. Zao, “Intraoperative magnetic resonance imaging and magnetic resonance imaging-guided therapy for brain tumors,” Neuroimaging Clin. N. Am. 12665-83 (2002).

E. E. Konofagou, J. Thierman, T. Karjalainen, and K. Hynynen, “The temperature dependence of ultrasound-stimulated acoustic emission,” Ultrasound Med. Biol. 28(3), 331-8 (2002).

N. McDannold , R. L. King, F. A. Jolesz, and K. Hynynen, “The use of quantitative temperature images to predict the optimal power for focused ultrasound surgery: in vivo verification in rabbit muscle and brain,” Med. Phys. 29(3), 356-65 (2002).

T. E. Vaughan and K. Hynynen, “Effects of parameter errors in the simulation of transcranial focused ultrasound,” Phys Med. Biol. 47(1), 37-45 (2002).

2001

G. T. Clement, J. Sun, and K. Hynynen, “The role of internal reflection in transskull phase distortion,” Ultrasonics 39(2), 109-13 (2001).

I. M. Hallaj, R. O. Cleveland, and K. Hynynen, “Simulations of the thermo-acoustic lens effect during focused ultrasound surgery,” J. Acoust. Soc. Am. 109(5 Pt 1), 2245-53 (2001).

M. Hayner and K. Hynynen, “Numerical analysis of ultrasonic transmission and absorption of oblique plane waves through the human skull,” J. Acoust. Soc. Am. 110(6), 3319-30 (2001).

M. D. Hurwitz, I. D. Kaplan, G. K. Svensson, K. Hynynen, and M. S. Hansen, “Feasibility and patient tolerance of a novel transrectal ultrasound hyperthermia system for treatment of prostate cancer,” Int. J. Hyperthermia 17(1), 31-7 (2001).

K. Hynynen, O. Pomeroy, D. N. Smith, P. E. Huber, N. J. McDannold, J. Kettenbach, J. Baum, S. Singer, and F. A. Jolesz, “MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast: a feasibility study,” Radiology 219(1), 176-85 (2001).

K. Hynynen, N. McDannold, N. Vykhodtseva , and F. A. Jolesz, “Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits,” Radiology 220(3), 640-6 (2001).

E. Konofagou, J. Thierman, and K. Hynynen, “A focused ultrasound method for simultaneous diagnostic and therapeutic applications--a simulation study,” Phys Med. Biol. 46(11), 2967-84 (2001).

K. Mahoney, T. Fjield, N. McDannold, G. Clement, and K. Hynynen, “Comparison of modelled and observed in vivo temperature elevations induced by focused ultrasound: implications for treatment planning,” Phys Med. Biol. 46(7), 1785-98 (2001).

N. J. McDannold, K. Hynynen, and F. A. Jolesz, “MRI monitoring of the thermal ablation of tissue: Effects of long exposure times,” J. Magn. Reson. Imaging 13(3), 421-7 (2001).

N. J. McDannold, K. Hynynen, K. Oshio, and R. V. Mulkern, “Temperature monitoring with line scan echo planar spectroscopic imaging (LSEPSI),” Med. Phys. 28(3), 346-55 (2001).

N. B. Smith, N. K. Merilees, K. Hynynen, and M. Dahleh, “Control system for an MRI compatible intracavitary ultrasound array for thermal treatment of prostate disease,” Int. J. Hyperthermia 17(3), 271-82 (2001).

N. B. Smith, J. M. Temkin, F. Shapiro, and K. Hynynen, “Thermal effects of focused ultrasound energy on bone tissue,” Ultrasound Med. Biol. 27(10), 1427-33 (2001).

N. Vykhodtseva, N. McDannold , H. Martin, R. T. Bronson, and K. Hynynen, “Apoptosis in ultrasound-produced threshold lesions in the rabbit brain,” Ultrasound. Med. Biol. 27(1), 111-7 (2001).

2000

O. Algan, H. Fosmire, K. Hynynen, B. Dalkin, H. Cui, G. Drach, B. Stea, and J. R. Cassady. “External beam radiotherapy and hyperthermia in the treatment of patients with locally advanced prostate carcinoma,” Cancer 89(2), 399-403 (2000).

G. T. Clement, J. Sun, T. Giesecke, and K. Hynynen. “A hemisphere array for non-invasive ultrasound brain therapy and surgery,” Phys Med Biol 45(12), 3707-19 (2000).

G. T. Clement, J. White, and K. Hynynen. “Investigation of a large-area phased array for focused ultrasound surgery through the skull,” Phys Med Biol 45(4), 1071-83 (2000).

G. T. Clement and K. Hynynen. “Field characterization of therapeutic ultrasound phased arrays through forward and backward planar projection,” J Acoust Soc Am 108(1), 441-6 (2000).

T. Fjield and K. Hynynen. “Method of reduction of the number of driving system channels for phased-array transducers using isolation transformers,” IEEE Trans Biomed Eng 47(1), 139-41 (2000).

K. Hynynen, N. J. McDannold, R. V. Mulkern, and F. A. Jolesz. “Temperature monitoring in fat with MRI,” Magn Reson Med 43(6), 901-4 (2000).

K. Kuroda, R. V. Mulkern, K. Oshio, L. P. Panych, T. Nakai, T. Moriya, S. Okuda, K. Hynynen, and F. A. Jolesz. “Temperature mapping using the water proton chemical shift: self-referenced method with echo-planar spectroscopic imaging,” Magn Reson Med 43(2), 220-5 (2000).

N. J. McDannold, R. L. King, F. A. Jolesz, and K. Hynynen. “Usefulness of MR Imaging-Derived Thermometry and Dosimetry in Determining the Threshold for Tissue Damage Induced by Thermal Surgery in Rabbits,” Radiology 216(2), 517-23 (2000).

N. J. McDannold, F. A. Jolesz. “Magnetic resonance image-guided thermal ablations,” Topics in MRI 11(3), 191-202 (2000).

S. D. Sokka and K. Hynynen. “The feasibility of MRI-guided whole prostate ablation with a linear aperiodic intracavitary ultrasound phased array,” Phys Med Biol 45(11), 3373-83 (2000).

Y. Sun, M. Sugawara, R. V. Mulkern, K. Hynynen, S. Mochizuki, M. Albert, and C. S. Zuo. “Simultaneous measurements of temperature and pH in vivo using NMR in conjunction with TmDOTP(5-),” NMR Biomed 13(8), 460-6 (2000).

N. Vykhodtseva, V. Sorrentino, F. A. Jolesz, R. T. Bronson, and K. Hynynen. “MRI detection of the thermal effects of focused ultrasound on the brain,” Ultrasound Med Biol 26(5), 871-80 (2000).

1999

A. H. Chung, F. A. Jolesz, and K. Hynynen. “Thermal dosimetry of a focused ultrasound beam in vivo by magnetic resonance imaging,” Med Phys 26(9), 2017-26 (1999).

D. R. Daum and K. Hynynen. “A 256 Element Ultrasonic Phased Array System for Treatment of Large Volumes of Deep Seated Tissue,” IEEE Trans Ultrason Ferroelectr Freq Contr 46(5), 1254-68 (1999).

D. R. Daum, N. B. Smith, R. King, and K. Hynynen. “In vivo demonstration of noninvasive thermal surgery of the liver and kidney using an ultrasonic phased array,” Ultrasound Med Biol 25(7), 1087-98 (1999).

D. R. Daum and K. Hynynen. “Theoretical design of a spherically sectioned phased array for ultrasound surgery of the liver,” Eur J Ultrasound 9(1), 61-9 (1999).

D. R. Daum and K. Hynynen. “Cutting edge acoustics. Non-invasive surgery using ultrasound,” IEEE Potentials 17(5), 17-20 (1999).

C. J. Diederich and K. Hynynen. “Ultrasound technology for hyperthermia,” Ultrasound Med Biol 25(6), 871-87 (1999).

T. Fjield, C. E. Silcox, and K. Hynynen. “Low-profile lenses for ultrasound surgery,” Phys Med Biol 44(7), 1803-13 (1999).

K. Foldes, K. Hynynen, S. Shortkroff, C. S. Winalski, V. Collucci, S. K. Koskinen, N. J. McDannold, and F. Jolesz. “Magnetic resonance imaging-guided focused ultrasound synovectomy,” Scand J Rheumatol 28(4), 233-7 (1999).

K. Hynynen and J. Sun. “Trans-skull ultrasound therapy: the feasibility of using image-derived skull thickness information to correct the phase distortion,” IEEE Trans Ultrason Ferroelectr Freq Contr 46(3), 752 (1999).

R. J. Lee, M. Buchanan, L. J. Kleine, and K. Hynynen. “Arrays of multielement ultrasound applicators for interstitial hyperthermia,” IEEE Trans Biomed Eng 46(7), 880-90 (1999).

N. J. McDannold, F. A. Jolesz, and K. Hynynen. “Determination of the optimal delay between sonications during focused ultrasound surgery in rabbits by using MR imaging to monitor thermal buildup in vivo,” Radiology 211(2), 419-26 (1999).

Y. Sharf, G. T. Clement, K. Hynynen, and R. G. Aarnink. “Absolute measurements of ultrasonic pressure by using high magnetic fields,” IEEE Trans Ultrason Ferroelectr Freq Contr 46(6), 1504 (1999).

N. B. Smith, M. T. Buchanan, and K. Hynynen. “Transrectal ultrasound applicator for prostate heating monitored using MRI thermometry,” Int J Radiat Oncol Biol Phys 43(1), 217-25 (1999).

J. Sun and K. Hynynen. “The potential of transskull ultrasound therapy and surgery using the maximum available skull surface area,” J Acoust Soc Am 105(4), 2519-27 (1999).

1998

D. R. Daum, M. T. Buchanan, T. Fjield, and K. Hynynen. “Design and evaluation of a feedback based phased array system for ultrasound surgery,” IEEE Trans Ultrason Ferroelectr Freq Contr 45(2), 431-8 (1998).

D. R. Daum and K. Hynynen. “Thermal dose optimization via temporal switching in ultrasound surgery,” IEEE Trans Ultrason Ferroelectr Freq Contr 45(1), 208 (1998).

E. Hutchinson , M. Dahleh, and K. Hynynen. “The feasibility of MRI feedback control for intracavitary phased array hyperthermia treatments,” Int J Hyperthermia 14(1), 39-56 (1998).

E. B. Hutchinson and K. Hynynen. “Intracavitary ultrasound phased arrays for prostate thermal therapies: MRI compatibility and in vivo testing,” Med Phys 25(12), 2392-9 (1998).

K. Hynynen and F. A. Jolesz. “Demonstration of potential noninvasive ultrasound brain therapy through an intact skull,” Ultrasound Med Biol 24(2), 275-83 (1998).

K. Kuroda, A. H. Chung, K. Hynynen, and F. A. Jolesz. “Calibration of water proton chemical shift with temperature for noninvasive temperature imaging during focused ultrasound surgery,” J Magn Reson Imaging 8(1), 175-81 (1998).

N. J. McDannold, K. Hynynen, D. Wolf, G. Wolf, and F. A. Jolesz. “MRI evaluation of thermal ablation of tumors with focused ultrasound,” J Magn Reson Imaging 8(1), 91-100 (1998).

I. A. Morocz, K. Hynynen, H. Gudbjartsson, S. Peled, V. Colucci, and F. A. Jolesz. “Brain edema development after MRI-guided focused ultrasound treatment,” J Magn Reson Imaging 8(1), 136-42 (1998).

R. V. Mulkern, L. P. Panych, N. J. McDannold, F. A. Jolesz, and K. Hynynen. “Tissue temperature monitoring with multiple gradient-echo imaging sequences,” J Magn Reson Imaging 8(2), 493-502 (1998).

N. B. Smith and K. Hynynen. “The feasibility of using focused ultrasound for transmyocardial revascularization,” Ultrasound Med Biol 24(7), 1045-54 (1998).

J. Sun and K. Hynynen. “Focusing of therapeutic ultrasound through a human skull: a numerical study,” J Acoust Soc Am 104(3 Pt 1), 1705-15 (1998).

T. Z. Wong, S. G. Silverman, J. R. Fielding, C. M. Tempany, K. Hynynen, and F. A. Jolesz. “Open-configuration MR imaging, intervention, and surgery of the urinary tract,” Urol Clin North Am 25(1), 113-22 (1998).

1997

T. Fjield, V. Sorrentino, H. Cline, and K. Hynynen. “Design and experimental verification of thin acoustic lenses for the coagulation of large tissue volumes,” Phys Med Biol 42(12), 2341-54 (1997).

T. Fjield and K. Hynynen. “The Combined Concentric-Ring and Sector-Vortex Phased Array for MRI Guided Ultrasound Surgery,” IEEE Trans Ultrason Ferroelectr Freq Contr 44(5), 1157-67 (1997).

K. Hynynen, N. I. Vykhodtseva, A. H. Chung, V. Sorrentino, V. Colucci, and F. A. Jolesz. “Thermal effects of focused ultrasound on the brain: determination with MR imaging,” Radiology 204(1), 247-53 (1997).

K. Hynynen, J. Dennie, J. E. Zimmer, W. N. Simmons, D. S. He, F. I. Marcus, and M. Aguirre. “Cylindrical ultrasonic transducers for cardiac catheter ablation,” IEEE Trans Biomed Eng 44(2), 144-51 (1997).

K. Kuroda, K. Oshio, A. H. Chung, K. Hynynen, and F. A. Jolesz. “Temperature mapping using the water proton chemical shift: a chemical shift selective phase mapping method,” Magn Reson Med 38(5), 845-51 (1997).

R. V. Mulkern, A. H. Chung, F. A. Jolesz, and K. Hynynen. “Temperature monitoring of ultrasonically heated muscle with RARE chemical shift imaging,” Med Phys 24(12), 1899-906 (1997).

1996

Chung A, Hynynen KH, Cline HE, Jolesz FA. Quantification of thermal exposure using proton resonance frequency shift. [Abstract] Proc SMR 4th Meeting, ISSN 1065-9889 1996;3:1751

A. H. Chung, K. Hynynen, V. Colucci, K. Oshio, H. E. Cline, and F. A. Jolesz. “Optimization of spoiled gradient-echo phase imaging for in vivo localization of a focused ultrasound beam,” Magn Reson Med 36(5), 745-52 (1996).

H. E. Cline, K. Hynynen, E. Schneider, C. J. Hardy, S. E. Maier, R. D. Watkins, and F. A. Jolesz. “Simultaneous magnetic resonance phase and magnitude temperature maps in muscle,” Magn Reson Med 35(3), 309-15 (1996).

L. Crum and K. Hynynen. “Sound therapy,” Phys World ( UK ) 9(8), 28 (1996).

X. Fan and K. Hynynen. “Ultrasound surgery using multiple sonications--treatment time considerations,” Ultrasound Med Biol 22(4), 471-82 (1996).

X. Fan and K. Hynynen. “A study of various parameters of spherically curved phased arrays for noninvasive ultrasound surgery,” Phys Med Biol 41(4), 591-608 (1996).

T. Fjield, X. Fan, and K. Hynynen. “A parametric study of the concentric-ring transducer design for MRI guided ultrasound surgery,” J Acoust Soc Am 100(2 Pt 1), 1220-30 (1996).

E. B. Hutchinson, M. T. Buchanan, and K. Hynynen. “Design and optimization of an aperiodic ultrasound phased array for intracavitary prostate thermal therapies,” Med Phys 23(5), 767-76 (1996).

E. B. Hutchinson and K. Hynynen. “Intracavitary ultrasound phased arrays for noninvasive prostate surgery,” IEEE Trans Ultrason Ferroelectr Freq Contr 43(6), 1032 (1996).

K. Hynynen, A. H. Chung, V. Colucci, and F. A. Jolesz. “Potential adverse effects of high-intensity focused ultrasound exposure on blood vessels in vivo,” Ultrasound Med Biol 22(2), 193-201 (1996).

K. Hynynen, W. R. Freund, H. E. Cline, A. H. Chung, R. D. Watkins, J. P. Vetro, and F. A. Jolesz. “A clinical, noninvasive, MR imaging-monitored ultrasound surgery method,” Radiographics 16(1), 185-95 (1996).

K. Hynynen. “Focused ultrasound surgery guided by MRI,” Science&Medicine 3(5), 62-71 (1996).

K. Hynynen, V. Colucci, A. Chung, and F. A. Jolesz. “Noninvasive arterial occlusion using MRI-guided focused ultrasound,” Ultrasound Med Biol 22(8), 1071-7 (1996).

K. Hynynen, A. Chung, T. Fjield, M. Buchanan, D. Daum, V. Colucci, P. Lopath, and F. A. Jolesz. “Feasibility of using ultrasound phased arrays for MRI monitored noninvasive surgery,” IEEE Trans Ultrason Ferroelectr Freq Contr 43(6), 1043 (1996).

N. T. Songhvi, K. Hynynen, and F. L. Lizzi. “New developments in therapeutic ultrasound,” IEEE Eng Med Biol Mag (USA) 15(6), 83 (1996).

1995

D. P. Anhalt, K. Hynynen, and R. B. Roemer. “Patterns of changes of tumour temperatures during clinical hyperthermia: implications for treatment planning, evaluation and control,” Int J Hyperthermia 11(3), 425-36 (1995).

H. E. Cline, K. Hynynen, R. D. Watkins, W. J. Adams, J. F. Schenck, R. H. Ettinger, W. R. Freund, J. P. Vetro, and F. A. Jolesz. “Focused US system for MR imaging-guided tumor ablation,” Radiology 194(3), 731-7 (1995).

C. A. Damianou, K. Hynynen, and F. Xiaobing. “Evaluation of accuracy of a theoretical model for predicting the necrosed tissue volume during focused ultrasound surgery,” IEEE Trans Ultrason Ferroelectr Freq Contr 42(2), 182 (1995).

X. Fan and K. Hynynen. “Control of the necrosed tissue volume during noninvasive ultrasound surgery using a 16-element phased array,” Med Phys 22(3), 297-306 (1995).

K. Hynynen, A. Chung, H. E. Cline, and F. A. Jolesz. “The in vivo evaluation of proton resonance frequency shift for temperature monitoring during long hyperthermia treatments,” Proc SMR 3rd Meeting, ISSN 1065-9889 1176 (1995).

K. Hynynen, C. A. Damianou, V. Colucci, E. Unger, H. H. Cline, and F. A. Jolesz. “MR monitoring of focused ultrasonic surgery of renal cortex: experimental and simulation studies,” J Magn Reson Imaging 5(3), 259-66 (1995).

K. Hynynen, A. Chung, V. Colucci, and F. A. Jolesz. “In vivo vascular effects of MRI guided focused ultrasound exposures,” Proc SMR 3rd Meeting, ISSN 1065-9889 498 (1995).

H. Montes and K. Hynynen. “A system for the simultaneous delivery of intraoperative radiation and ultrasound hyperthermia,” Int J Hyperthermia 11(1), 109-19 (1995).

N. I. Vykhodtseva, K. Hynynen, and C. Damianou. “Histologic effects of high intensity pulsed ultrasound exposure with subharmonic emission in rabbit brain in vivo,” Ultrasound Med Biol 21(7), 969-79 (1995).

J. E. Zimmer, K. Hynynen, D. S. He, and F. Marcus. “The feasibility of using ultrasound for cardiac ablation,” IEEE Trans Biomed Eng 42(9), 891-7 (1995).

1994

M. T. Buchanan and K. Hynynen. “Design and experimental evaluation of an intracavitary ultrasound phased array system for hyperthermia,” IEEE Trans Biomed Eng 41(12), 1178-87 (1994).

H. E. Cline, K. Hynynen, C. J. Hardy, R. D. Watkins, J. F. Schenck, and F. A. Jolesz. “MR temperature mapping of focused ultrasound surgery,” Magn Reson Med 31(6), 628-36 (1994).

C. Damianou and K. Hynynen. “The effect of various physical parameters on the size and shape of necrosed tissue volume during ultrasound surgery,” J Acoust Soc Am 95(3), 1641-9 (1994).

X. Fan and K. Hynynen. “The effects of curved tissue layers on the power deposition patterns of therapeutic ultrasound beams,” Med Phys 21(1), 25-34 (1994).

D. S. He, J. E. Zimmer, K. Hynynen, F. I. Marcus, A. C. Caruso, L. F. Lampe, and M. L. Aguirre. “Preliminary results using ultrasound energy for ablation of the ventricular myocardium in dogs,” Am J Cardiol 73(13), 1029-31 (1994).

K. Hynynen, A. Darkazanli, C. A. Damianou, E. Unger, and J. F. Schenck. “The usefulness of a contrast agent and gradient-recalled acquisition in a steady-state imaging sequence for magnetic resonance imaging-guided noninvasive ultrasound surgery,” Invest Radiol 29(10), 897-903 (1994).

S. J. Tu, K. Hynynen, and R. B. Roemer. “Simulation of bidirectional ultrasound hyperthermia treatments of neck tumours,” Int J Hyperthermia 10(5), 707 (1994).

N. I. Vykhodtseva, K. Hynynen, and C. Damianou. “Pulse duration and peak intensity during focused ultrasound surgery: theoretical and experimental effects in rabbit brain in vivo,” Ultrasound Med Biol 20(9), 987-1000 (1994).

1993

H. E. Cline, J. F. Schenck, R. D. Watkins, K. Hynynen, and F. A. Jolesz. “Magnetic resonance-guided thermal surgery,” Magn Reson Med 30(1), 98-106 (1993).

M. K. Croghan, D. S. Shimm, K. Hynynen, D. P. Anhalt, S. L. Valencic, A. M. Fletcher, J. M. Kittleson, and T. C. Cetas. “A phase I study of the toxicity of regional hyperthermia with systemic warming,” Am J Clin Oncol 16(4), 354-8 (1993).

C. Damianou and K. Hynynen. “Focal spacing and near-field heating during pulsed high temperature ultrasound therapy,” Ultrasound Med Biol 19(9), 777-87 (1993).

Darkazanli, K. Hynynen, E. C. Unger, and J. F. Schenck. “On-line monitoring of ultrasonic surgery with MR imaging,” J Magn Reson Imaging 3(3), 509-14 (1993).

H. Fosmire, K. Hynynen, G. W. Drach, B. Stea, P. Swift, and J. R. Cassady. “Feasibility and toxicity of transrectal ultrasound hyperthermia in the treatment of locally advanced adenocarcinoma of the prostate,” Int J Radiat Oncol Biol Phys 26(2), 253-9 (1993).

K. Hynynen, A. Darkazanli, E. Unger, and J. F. Schenck. “MRI-guided noninvasive ultrasound surgery,” Med Phys 20(1), 107-15 (1993).

K. Hynynen. “Acoustic power calibrations of cylindrical intracavitary ultrasound hyperthermia applicators,” Med Phys 20(1), 129-34 (1993).

K. Hynynen, A. Darkazanli, C. A. Damianou, E. Unger, and J. F. Schenck. “Tissue thermometry during ultrasound exposure,” Eur Urol 23 Suppl 112-6 (1993).

K. Hynynen, C. Damianou, A. Darkazanli, E. Unger, and J. F. Schenck. “The feasibility of using MRI to monitor and guide noninvasive ultrasound surgery [letter],” Ultrasound Med Biol 19(1), 91-2 (1993).

K. Hynynen and K. L. Davis. “Small cylindrical ultrasound sources for induction of hyperthermia via body cavities or interstitial implants,” Int J Hyperthermia 9(2), 263-74 (1993).

E. G. Moros, A. W. Dutton, R. B. Roemer, M. Burton, and K. Hynynen. “Experimental evaluation of two simple thermal models using hyperthermia in muscle in vivo,” Int J Hyperthermia 9(4), 581-98 (1993).

1992

D. Anhalt and K. Hynynen. “Thermocouples--the Arizona experience with in-house manufactured probes,” Med Phys 19(5), 1325-33 (1992).

H. E. Cline, J. F. Schenck, K. Hynynen, R. D. Watkins, S. P. Souza, and F. A. Jolesz. “MR-guided focused ultrasound surgery,” J Comput Assist Tomogr 16(6), 956-65 (1992).

L. N. Dorr and K. Hynynen. “The effects of tissue heterogeneities and large blood vessels on the thermal exposure induced by short high-power ultrasound pulses,” Int J Hyperthermia 8(1), 45-59 (1992).

X. Fan and K. Hynynen. “The effect of wave reflection and refraction at soft tissue interfaces during ultrasound hyperthermia treatments,” J Acoust Soc Am 91(3), 1727-36 (1992).

K. Hynynen. “The feasibility of interstitial ultrasound hyperthermia,” Med Phys 19(4), 979-87 (1992).

W. L. Lin, R. B. Roemer, E. G. Moros, and K. Hynynen. “Optimization of temperature distributions in scanned, focused ultrasound hyperthermia,” Int J Hyperthermia 8(1), 61-78 (1992).

E. G. Moros and K. Hynynen. “A comparison of theoretical and experimental ultrasound field distributions in canine muscle tissue in vivo,” Ultrasound Med Biol 18(1), 81-95 (1992).

1991

C. J. Diederich and K. Hynynen. “The feasibility of using electrically focused ultrasound arrays to induce deep hyperthermia via body cavities,” IEEE Trans Ultrason Ferroelectr Freq Contr 38(3), 207 (1991).

A. N. Guthkelch, L. P. Carter, J. R. Cassady, K. Hynynen, R. P. Iacono, P. C. Johnson, E. A. Obbens, R. B. Roemer, J. F. Seeger, and D. S. Shimm. “Treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation: results of a phase I trial,” J Neurooncol 10(3), 271-84 (1991).

K. Hynynen. “The threshold for thermally significant cavitation in dog's thigh muscle in vivo,” Ultrasound Med Biol 17(2), 157-69 (1991).

K. Hynynen. “The role of nonlinear ultrasound propagation during hyperthermia treatments,” Med Phys 18(6), 1156-63 (1991).

1990

B. E. Billard, K. Hynynen, and R. B. Roemer. “Effects of physical parameters on high temperature ultrasound hyperthermia,” Ultrasound Med Biol 16(4), 409-20 (1990).

C. J. Diederich and K. Hynynen. “The development of intracavitary ultrasonic applicators for hyperthermia: a design and experimental study,” Med Phys 17(4), 626-34 (1990).

K. Hynynen and B. A. Lulu. “Hyperthermia in cancer treatment,” Invest Radiol 25(7), 824-34 (1990).

K. Hynynen, D. Shimm, D. Anhalt, B. Stea, H. Sykes, J. R. Cassady, and R. B. Roemer. “Temperature distributions during clinical scanned, focused ultrasound hyperthermia treatments,” Int J Hyperthermia 6(5), 891-908 (1990).

K. Hynynen. “Hot spots created at skin-air interfaces during ultrasound hyperthermia,” Int J Hyperthermia 6(6), 1005-12 (1990).

W. L. Lin, R. B. Roemer, and K. Hynynen. “Theoretical and experimental evaluation of a temperature controller for scanned focused ultrasound hyperthermia,” Med Phys 17(4), 615-25 (1990).

E. G. Moros, R. B. Roemer, and K. Hynynen. “Pre-focal plane high-temperature regions induced by scanning focused ultrasound beams,” Int J Hyperthermia 6(2), 351-66 (1990).

J. Zaerr, R. B. Roemer, and K. Hynynen. “Computer-controlled dynamic phantom for ultrasound hyperthermia studies,” IEEE Trans Biomed Eng 37(11), 1115-8 (1990).

1980s

C. J. Diederich and K. Hynynen. “Induction of hyperthermia using an intracavitary multielement ultrasonic applicator,” IEEE Trans Biomed Eng 36(4), 432-8 (1989).

K. Hynynen and D. K. Edwards. “Temperature measurements during ultrasound hyperthermia,” Med Phys 16(4), 618-26 (1989).

K. Hynynen, D. DeYoung, M. Kundrat, and E. Moros. “The effect of blood perfusion rate on the temperature distributions induced by multiple, scanned and focused ultrasonic beams in dogs' kidneys in vivo,” Int J Hyperthermia 5(4), 485-97 (1989).

K. Hynynen. “Effect of tissue perfusion on temperature elevation,” Ultrasound Med Biol 15 Suppl 141-3 (1989).

D. Anhalt and K. Hynynen. “The efficiency of clinical microwave applicators measured by a calorimetric method,” Med Phys 15(6), 919-21 (1988).

K. Hynynen and D. DeYoung. “Temperature elevation at muscle-bone interface during scanned, focused ultrasound hyperthermia,” Int J Hyperthermia 4(3), 267-79 (1988).

E. G. Moros, R. B. Roemer, and K. Hynynen. “Simulations of scanned focused ultrasound hyperthermia. The effects of scanning speed and pattern on the temperature fluctuations at the focal depth,” IEEE Trans Ultrason Ferroelectr Freq Contr 35(5), 552 (1988).

D. S. Shimm, K. Hynynen, D. P. Anhalt, R. B. Roemer, and J. R. Cassady. “Scanned focussed ultrasound hyperthermia: initial clinical results,” Int J Radiat Oncol Biol Phys 15(5), 1203-8 (1988).

K. Hynynen. “Demonstration of enhanced temperature elevation due to nonlinear propagation of focussed ultrasound in dog's thigh in vivo,” Ultrasound Med Biol 13(2), 85-91 (1987).

K. Hynynen, R. Roemer, D. Anhalt, C. Johnson, Z. X. Xu, W. Swindell, and T. Cetas. “A scanned, focused, multiple transducer ultrasonic system for localized hyperthermia treatments,” Int J Hyperthermia 3(1), 21-35 (1987).

J. Tobias, K. Hynynen, R. Roemer, A. N. Guthkelch, A. S. Fleischer, and J. Shively. “An ultrasound window to perform scanned, focused ultrasound hyperthermia treatments of brain tumors,” Med Phys 14(2), 228-34 (1987).

K. Hynynen, R. Roemer, E. Moros, C. Johnson, and D. Anhalt. “The effect of scanning speed on temperature and equivalent thermal exposure distributions during ultrasound hyperthermia in vivo,” IEEE Trans Microw Theory Tech MTT-34(5), 552 (1986).

C. J. Martin, K. Hynynen, and D. J. Watmough. “Measurement of ultrasound energy density distributions in vivo,” Ultrasound Med Biol 10(6), 701-8 (1984).

K. Hynynen, D. J. Watmough, J. R. Mallard, and M. Fuller. “The construction and assessment of lenses for local treatment of malignant tumours by ultrasound,” Ultrasound Med Biol 9(1), 33-8 (1983).

K. Hynynen, D. J. Watmough, J. R. Mallard, and M. Fuller. “Local hyperthermia induced by focussed and overlapping ultrasonic fields--an in vivo demonstration,” Ultrasound Med Biol 9(6), 621-7 (1983).

K. Hynynen, C. J. Martin, D. J. Watmough, and J. R. Mallard. “Errors in temperature measurement by thermocouple probes during ultrasound induced hyperthermia,” Br J Radiol 56(672), 969-70 (1983).

K. Hynynen, D. J. Watmough, and J. R. Mallard. “The effect of thermal conduction during local hyperthermia induced by ultrasound: a phantom study,” Br J Cancer Suppl 45(5), 68-70 (1982).

K. Hynynen, D. J. Watmough, and J. R. Mallard. “Design of ultrasonic transducers for local hyperthermia,” Ultrasound Med Biol 7(4), 397-402 (1981).

K. Hynynen, D. J. Watmough, and J. R. Mallard. “The effects of some physical factors on the production of hyperthermia by ultrasound in neoplastic tissues,” Radiat Environ Biophys 19(3), 215-26 (1981).